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Fentanyl is now the deadliest drug in America, beating out heroin and oxycodone which had previously been involved in the most overdose fatalities between 2011 and 2016. In fact, the report released Wednesday by the Centers for Disease Control and Prevention (CDC), discovered a 113 percent increase per year between 2013 and 2016 in the number of deaths involving fentanyl.

Fentanyl is a synthetic opioid that is both cheap to produce and up to 50 times more powerful than heroin and 100 times more potent than morphine. The drug can be absorbed through the skin, posing a risk to first responders or those unaware of its presence, and can be inhaled in powder form which also presents a danger.

“Among drug overdose deaths that mentioned at least one specific drug, oxycodone ranked first in 2011, heroin ranked first from 2012 through 2015, and fentanyl ranked first in 2016. Cocaine ranked second or third throughout the study period,” according to the report.

DOCTORS CAUGHT BETWEEN STRUGGLING OPIOID PATIENTS AND CRACKDOWN ON PRESCRIPTIONS

Researchers compiled data from 64,000 death certificates on U.S. overdose deaths and compared them with the five previous years. Meth use also played a larger role in fatalities than previous years, with the number of overdose deaths more than tripling between 2011 and 2016.

“From 2011 through 2016, the number of drug overdose deaths increased by 54 percent, from 41,340 deaths in 2011 to 64,632 deaths in 2016. The most frequently mentioned drugs involved in these deaths were the opioids heroin, oxycodone, methadone, morphine, hydrocodone and fentanyl; the benzodiazepines alprazolam and diazepam; and the stimulants cocaine and methamphetamine, the report said.

The percentage of overdose deaths involving meth grew from less than 5 percent to nearly 11 percent.

AS DOCTORS TAPER OR END OPIOID PRESCRIPTIONS, MANY PATIENTS DRIVEN TO DESPAIR, SUICIDE

“It’s a very dangerous drug to mess around with,” Theodore Cicero, a Washington University researcher who studies the rise of meth use among people who use opioids, told the Associated Press.

Cicero said some opioid abusers or heroin users have been turning to meth, which is a stimulant, to offset the down effects of other drugs.

The Associated Press contributed to this report.