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NASA's SpaceX Crew-2 mission successfully launched into orbit early Friday morning.

With weather conditions clear, the Elon Musk-owned Falcon 9 rocket and Crew Dragon spacecraft Endeavour launched from Florida's Kennedy Space Center at 5:49 a.m. ET.

SPACEX LAUNCHES NASA CREW FOR MISSION TO ISS ON REUSED ROCKET AFTER DELAY

NASA astronauts Megan McArthur and Crew-2 Commander Shane Kimbrough, Japan Aerospace Exploration Agency (JAXA) astronaut Akihiko Hoshide and European Space Agency (ESA) astronaut Thomas Pesquet are en route to the International Space Station (ISS).

This March 3, 2021 photo made available by SpaceX shows mission specialist Thomas Pesquet of the European Space Agency, pilot Megan McArthur and commander Shane Kimbrough of NASA, and mission specialist Akihiko Hoshide of the Japan Aerospace Exploration Agency, the crew for its third astronaut launch to the International Space Station, at the SpaceX training facility in Hawthorne, Calif. (SpaceX via AP)

This March 3, 2021 photo made available by SpaceX shows mission specialist Thomas Pesquet of the European Space Agency, pilot Megan McArthur and commander Shane Kimbrough of NASA, and mission specialist Akihiko Hoshide of the Japan Aerospace Exploration Agency, the crew for its third astronaut launch to the International Space Station, at the SpaceX training facility in Hawthorne, Calif. (SpaceX via AP) (SpaceX via AP)

"Glad to be back in space for all of us," Kimbrough radioed flight controllers after reaching orbit. 

"Predawn launches are always amazing," Steve Jurczyk, NASA's acting administrator, said during live coverage of the event. "It was thrilling to see."

Their stay aboard the ISS is slated to last for six months. 

The SpaceX Crew Dragon spacecraft -- now traveling at thousands of miles per hour -- is expected to dock at the ISS on Saturday at approximately 5:10 a.m. ET.

The flight marks SpaceX's third crew flight in less than a year, the second crew rotation on a commercial spacecraft mission and the first with two international partner astronauts, as well as the first time SpaceX has reused a capsule and rocket to launch astronauts for NASA.

The rocket was last used in November on SpaceX's second astronaut flight.

Space.com reported Friday that SpaceX had replaced some valves and thermal shielding and installed new parachutes on the capsule.

A SpaceX Falcon 9 rocket with the Crew Dragon space capsule lifts off from pad 39A at the Kennedy Space Center in Cape Canaveral, Fla., Friday, April 23, 2021. (AP Photo/John Raoux)

A SpaceX Falcon 9 rocket with the Crew Dragon space capsule lifts off from pad 39A at the Kennedy Space Center in Cape Canaveral, Fla., Friday, April 23, 2021. (AP Photo/John Raoux) (AP Photo/John Raoux)

Initially scheduled to lift off on Thursday morning, the flight was delayed by inclement weather.

The Crew-2 members will join NASA astronauts Mark Vande Hei, Michael Hopkins, Victor Glover and Shannon Walker, JAXA astronaut Soichi Noguchi and Russian cosmonauts Oleg Novitskiy and Pyotr Dubrov.

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The Crew-1 team that arrived last November is scheduled to return to Earth on April 28.

Coverage of the crew's 23-hour ride and docking will continuously air live on NASA Television and the agency's app and website.