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Purdue’s undefeated streak to start the 2022-23 college basketball season came to a screeching halt Monday night against unranked Rutgers. 

The Scarlet Knights defeated the Boilermakers for the second time in two seasons, handing No. 1 Purdue its first loss of the season, 65-64. 

Cam Spencer celebrates after hitting go-ahead three

Rutgers guard Cam Spencer, #10, celebrates after hitting the go ahead basket in the closing seconds during the second half of an NCAA college basketball game against Purdue in West Lafayette, Indiana, Monday, Jan. 2, 2023. Rutgers defeated Purdue 65-64.  (AP Photo/Michael Conroy)

Rutgers took a 10-point lead into halftime but needed a three-pointer from senior guard Cam Spencer with 13.3 seconds left to regain the lead for good on the road. 

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"We knew it was going to be a battle all night, and we made some plays down the stretch," Rutgers head coach Steve Pikiell said. "We’re excited to come away with a win in such a tough place."

Purdue had two chances to win the game following Spencer’s three, but the Boilermakers failed to convert, including a missed three by junior guard Brandon Newman with under five seconds left in the game. 

Rutgers center Clifford Omoruyi after beating Purdue

Rutgers center Clifford Omoruyi, #11, celebrates following an NCAA college basketball game against Purdue in West Lafayette, Indiana, Monday, Jan. 2, 2023. Rutgers defeated Purdue 65-64.  (AP Photo/Michael Conroy)

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"I just thought at the end of the day, Rutgers was mentally and physically tougher, even if we had won the game," Purdue coach Matt Painter said. "I thought we could have if we had gotten a stop or two there."

Last season, Rutgers beat then-No.1 Purdue on a half-court buzzer-beater in front of the Scarlet Knight home crowd. 

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On Monday, the game-winning shot silenced a raucous crowd at Mackey Arena in West Lafayette, Indiana. 

"Coach drew up a great play but the way they played it we had to go to something else," Spencer said.

Rutgers players celebrate after beating Purdue

The Rutgers players celebrate after defeating Purdue in 65-64 in an NCAA college basketball game in West Lafayette, Indiana, Monday, Jan. 2, 2023.  (AP Photo/Michael Conroy)

Purdue was led by center Zach Edey, who scored 19 points while grabbing 11 rebounds. 

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The Boilermakers have been the No. 1 team in the country since Week 6 of the college basketball season. 

The win moves Rutgers to 10-4 on the season and 2-1 in Big Ten play. 

The Associated Press contributed to this report