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Actor Bob Saget is dead after being found in a hotel room in Orlando on Sunday, according to the Orange County Sheriff's Office.

"Earlier today, deputies were called to the Ritz-Carlton Orlando, Grande Lakes for a call about an unresponsive man in a hotel room. The man was identified as Robert Saget & pronounced deceased on scene. Detectives found no signs of foul play or drug use in this case," the tweet read.

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Bob Saget attends MegaCon Orlando 2021 at Orange County Convention Center

Bob Saget attends MegaCon Orlando 2021 at Orange County Convention Center on August 14, 2021 in Orlando, Florida. (Photo by Gerardo Mora/Getty Images)

Saget was 65 years old.

A spokesperson for the sheriff's office told Fox News that deputies responded to a call at the Ritz-Carlton Orlando just after 4 p.m and found Saget unresponsive in a hotel room, and was pronounced dead on the scene. The Orange County Fire Rescue Department also responded to the call.

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Bob Saget is pictured on June 26, 1987

Bob Saget is pictured on June 26, 1987 (Photo by ABC Photo Archives/Disney General Entertainment Content via Getty Images)

According to the spokesperson, the Medical Examiner's Office will determine the cause of death.

Saget starred in the hit show "Full House," where he played a role as Danny Tanner.

Saget's last tweet was at 3:42 a.m. on Sunday, posting a picture from a comedy show where he had performed in Jacksonville.

 "Loved tonight’s show @PV_ConcertHall in Jacksonville. Appreciative audience. Thanks again to @RealTimWilkins for opening. I had no idea I did a 2 hr set tonight. I’m happily addicted again to this shit. Check http://BobSaget.com for my dates in 2022," he tweeted.

'Full House' actor Bob Saget

Bob Saget addressed his 'Full House' co-star Lori Loughlin, who is embattled in the ongoing college admissions scandal. (ABC/Craig Sjodin)

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Saget recently began a podcast called "Bob Saget’s Here For You," which his website describes as a "one of a kind stream of consciousness storytelling and real and honest conversations with amazing guests."

Bob Saget's father, Benjamin Saget, died on Jan. 30, 2007 after complications from congestive heart failure, according to the Los Angeles Times.

Dr. Marc Siegel, Fox News medical analyst and professor of medicine at New York University Langone Medical Center, said that heart disease runs in families, but added that he can't speculate on the exact cause of Saget's death.

Siegel added that around 250,000 to 400,000 people have a sudden cardiac arrest every year in the United States.

"250,000 to 400,000 people have sudden cardiac arrest every year in U.S. Most have underlying heart issues but may not be known. 95 percent die from it, majority over 65, male," Siegel said.