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Bob Saget, the comedian, actor, and star of the TV sitcom "Full House" and the Netflix sequel "Fuller House," died Sunday evening in a hotel in Orlando, Florida, police confirmed.

The Philadelphia-born star was 65 years old.

Reaction to the news of his death began pouring out on Twitter as the news broke Sunday night.

'FULL HOUSE' STAR BOB SAGET FOUND DEAD AT FLORIDA HOTEL AT THE AGE OF 65

Saget's "Full House" co-stars Candace Cameron Bure and John Stamos spoke out, both expressing how much they loved the late star.  

"Bob was so special to me and I’ll be sad about this day forever," Artie Lange told Fox News Digital in a statement. "Please be kind like Bob always was and consider donating to the National Scleroderma Foundation. It would mean everything to him."

"I was completely shocked at this news," June Lockhart told Fox News Digital in a statement. "He was sweet, consistently sweet. I loved working with him and thought he was just a dear. Very professional and always and genuinely funny."

"Bob was at my house in October interviewing me for a documentary. He was sharp and dark and funny as always and we were gonna catch up over coffee when he was done editing and now I’m crying F--K," Patton Oswalt wrote on Twitter.

"R.I.P. buddy. Life can turn to s--t in one moment. My heart aches for his whole [family] .In often a ruthless business he was historically not just hilarious but more importantly one of the kindest human beings I ever met in my career," Richard Lewis tweeted."

"He was one of the few comedians who didn’t give a damn about upsetting anyone. He said what he wanted to say without regret," Greg Gutfeld shared with Fox News Digital.

"Sad day for the comedy world," comedian Steve Martin tweeted.

Comedian Jim Gaffigan tweeted: "OMG! RIP. What a warm kind man we lost. The world has lost one of the nicest."

Comedian Jeff Ross – a longtime friend of Saget delivered a sound tribute to his late pal on Monday in an Instagram post that showed archival pictures of the two laughing while on vacation, on red carpets, on FaceTime, at dinner with other comedy greats, on stage together and even at what appears to be a reception of some kind.

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"I spent yesterday in Bob’s kitchen crying, eating and even laughing with his awesome wife Kelly, a few of our close pals and Bob’s wonderful cast mates," Ross wrote in the emotional scribe. "Yes it was a full house but it still felt very very empty without our star. Bob made everything better and losing him hasn’t set in for me. But in a way I think this is the easy part. The hard part will be next time I need advice or some cheering up or a pastrami sandwich at 2 am after a break up and my pal Bob isn’t around to get me through it.

"I hope everyone reading this has a friend like Bob," Ross concluded."