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Two motorists were killed and a passenger critically injured on Interstate 295 on Monday when a motorist traveled the wrong way, causing a head-on collision, state police said. Busy holiday traffic came to a standstill for hours.

A motorist from Oklahoma was killed and his spouse injured when a vehicle driven by a local resident entered the highway about 10 a.m. traveling south in the northbound lanes, state police said.

The collision happened near Exit 11 in Falmouth, a few miles north of Portland.

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Maine Fox News graphic

A head-on collision near Portland, Maine, killed two people and critically injured a third.

The highway was closed for about three hours on Memorial Day.

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Both drivers were pronounced dead at the scene, state police said. The Oklahoma motorist's wife, critically injured, was taken to Maine Medical Center in Portland.